| | Statistic | FOR | OPP |
| Total Yards per Game | 315.3 | 341.7 |
| Rushing YDS per ATT | 4.4 | 3.7 |
| Passing YDS per ATT | 6.8 | 6.7 |
| Passing Comp % | 0.584 | 0.618 |
| Total YDS per Play | 5.7 | 5.3 |
| Total YDS per Point | 13.7 | 12.4 |
|
| Injury |
| [QB] Alex Smith IR - Shoulder - 09/07/08 |
| [CB] Shawntae Spencer IR - Knee - 09/24/08 |
| [WR] Arnaz Battle missed last game, "?" - Foot - 11/16/08 |
| [OL] Barry Sims missed last game, "?" - Leg - 11/16/08 |
| [S] Dashon Goldson missed last game, "?" - Knee - 11/16/08 |
| [WR] Josh Morgan missed last game, "?" - Groin - 11/16/08 |
| [FB] Zak Keasey IR - Bicep - 10/13/08 |